Deciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brain

Highlights • Fam107B is the unique paralog of DRR1, and both feature predicted GRE sequences. • Fam107B mRNA is expressed in layered structures during dorsal brain development. • The expression of Fam107B in the mouse brain suggests a role in corticogenesis. • Fam107B mRNA is expressed in neurogenic...

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Veröffentlicht in:	Neuroscience 2015-04, Vol.290, p.147-158
Hauptverfasser:	Masana, M, Jukic, M.M, Kretzschmar, A, Wagner, K.V, Westerholz, S, Schmidt, M.V, Rein, T, Brodski, C, Müller, M.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Amino Acid Sequence Animals Brain - drug effects Brain - growth & development Brain - metabolism Chronic Disease corticogenesis Dexamethasone - pharmacology Dominance-Subordination DRR1 – Fam107A – Tu3A Fam107B – HITS glucocorticoid receptor Glucocorticoids - pharmacology In Situ Hybridization Male Mice Mice, Inbred C57BL Molecular Sequence Data Neurology Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - metabolism RNA, Messenger - metabolism Sequence Homology, Amino Acid Stem Cell Niche - drug effects Stem Cell Niche - physiology stress Stress, Psychological - metabolism Time Factors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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Zusammenfassung:	Highlights • Fam107B is the unique paralog of DRR1, and both feature predicted GRE sequences. • Fam107B mRNA is expressed in layered structures during dorsal brain development. • The expression of Fam107B in the mouse brain suggests a role in corticogenesis. • Fam107B mRNA is expressed in neurogenic niches in the adult mouse brain. • Compared to DRR1, Fam107B is unaltered by glucocorticoids in the adult hippocampus.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.01.026