Toxicity effects of profenofos on embryonic and larval development of Zebrafish ( Danio rerio )

Highlights • Profenofos is highly toxic to zebrafish embryos with 96 h LC50 value of 1.56 mg/L. • It induces several morphological abnormalities in a concentration dependent manner. • The percent hatchability was significantly lower than that of the control. • Abnormal development of heart leads to...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2015-03, Vol.39 (2), p.887-897
Hauptverfasser:	Pamanji, Rajesh, Yashwanth, B, Bethu, M.S, Leelavathi, S, Ravinder, K, Venkateswara Rao, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Adipose Tissue - abnormalities Animals Behavior, Animal - drug effects Cholinesterase Inhibitors - toxicity Danio rerio Developmental toxicity Embryo, Nonmammalian - abnormalities Embryo, Nonmammalian - drug effects Embryo, Nonmammalian - enzymology Embryonic Development - drug effects Emergency Freshwater Head - abnormalities Heart Defects, Congenital - chemically induced Insecticides - toxicity Motor Activity - drug effects Organothiophosphates - toxicity Profenofos Swimming behavior Tail - abnormalities Yolk Sac - abnormalities Zebrafish Zebrafish - abnormalities Zebrafish - embryology Zebrafish - metabolism
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Zusammenfassung:	Highlights • Profenofos is highly toxic to zebrafish embryos with 96 h LC50 value of 1.56 mg/L. • It induces several morphological abnormalities in a concentration dependent manner. • The percent hatchability was significantly lower than that of the control. • Abnormal development of heart leads to brachycardia. • Whole-body AChE inhibition resulted altered locomotor (swimming) behaviour.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.02.020