Treadmill exercise enhances synaptic plasticity, but does not alter β-amyloid deposition in hippocampi of aged APP/PS1 transgenic mice

Highlights • Treadmill exercise prevents impairment of spatial learning and memory in aged APP/PS1 mice. • Synaptic plasticity is involved in exercise-induced cognitive improvement in aged AD mice. • Alterations in soluble Aβ levels may contribute to the beneficial effects of treadmill exercise....

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Veröffentlicht in:	Neuroscience 2015-07, Vol.298, p.357-366
Hauptverfasser:	Zhao, G, Liu, H.L, Zhang, H, Tong, X.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - rehabilitation Alzheimer’s disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Animals APP/PS1 transgenic mice Disease Models, Animal Electric Stimulation Exercise Test Hippocampus - metabolism Hippocampus - pathology Humans learning and memory Maze Learning - physiology Mice Mice, Transgenic Mutation - genetics Neurology Neuronal Plasticity - physiology Physical Conditioning, Animal - methods Presenilin-1 - genetics Reaction Time - genetics Spatial Memory - physiology synaptic plasticity Synaptic Potentials - genetics treadmill exercise β-amyloid
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Zusammenfassung:	Highlights • Treadmill exercise prevents impairment of spatial learning and memory in aged APP/PS1 mice. • Synaptic plasticity is involved in exercise-induced cognitive improvement in aged AD mice. • Alterations in soluble Aβ levels may contribute to the beneficial effects of treadmill exercise.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.04.038