Gene Regulation: It Matters Who You Hang Out With

How broadly expressed transcription factors contribute to tissue-specific gene expression is not well understood. Andzelm, Cherry et al. (2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specif...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2015-04, Vol.86 (1), p.7-9
Hauptverfasser:	Masuda, Tomohiro, Berlinicke, Cynthia A., Zack, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Deoxyribonucleic acid Disease DNA DNA methylation Gene expression Gene Expression Regulation, Developmental - genetics Homeodomain Proteins - metabolism Nervous system Photoreceptor Cells - physiology Photoreceptors Proteins Prunus Retina Retina - cytology Rodents Trans-Activators - metabolism Transcription factors
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Beschreibung
Zusammenfassung:	How broadly expressed transcription factors contribute to tissue-specific gene expression is not well understood. Andzelm, Cherry et al. (2015) demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific transcription factor CRX. How broadly expressed transcription factors contribute to tissue-specific gene expression is not well understood. Andzelm, Cherry et al. demonstrate that myocyte enhancer factor 2D (MEF2D) binds and activates retina-specific regulatory regions by cooperative interaction with the tissue-specific transcription factor CRX.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2015.03.057