Germinal Center Quality Control: Death by Fas

Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal center. Fas is a cell surface death receptor critical for immune regulat...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-05, Vol.42 (5), p.783-785
1. Verfasser:	Allen, Christopher D.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoantibodies - immunology B-Lymphocytes - cytology fas Receptor - immunology Germinal Center - cytology Germinal Center - immunology Humans Immune system Immunoglobulin E - immunology Immunoglobulins Mutation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Fas is a cell surface death receptor critical for immune regulation. In this issue of Immunity, Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal center. Fas is a cell surface death receptor critical for immune regulation. Butt et al. (2015) show that Fas eliminates B cells that have become uncoupled from positive and negative selection in the germinal center.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2015.05.005