The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

Highlights • IL-6 has pro-inflammatory and anti-inflammatory activities. • IL-6 is involved in many autoimmune diseases. • IL-6 trans-signaling via the soluble IL-6 receptor is mainly pro-inflammatory. • Classic IL-6 signaling via the membrane bound IL-6R is regenerative and protective. • Specific b...

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Veröffentlicht in:	Current opinion in immunology 2015-06, Vol.34, p.75-82
Hauptverfasser:	Garbers, Christoph, Aparicio-Siegmund, Samadhi, Rose-John, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal, Humanized - therapeutic use Humans Inflammation - drug therapy Inflammation - immunology Interleukin-6 - immunology Interleukin-6 - metabolism Receptors, Interleukin-6 - metabolism Signal Transduction STAT3 Transcription Factor - metabolism
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Beschreibung
Zusammenfassung:	Highlights • IL-6 has pro-inflammatory and anti-inflammatory activities. • IL-6 is involved in many autoimmune diseases. • IL-6 trans-signaling via the soluble IL-6 receptor is mainly pro-inflammatory. • Classic IL-6 signaling via the membrane bound IL-6R is regenerative and protective. • Specific blockade of IL-6 trans-signaling might be a superior alternative to global blockade of IL-6.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2015.02.008