Treatment with granulocyte colony-stimulating factor in patients with repetitive implantation failures and/or recurrent spontaneous abortions

Highlights • Granulocyte colony-stimulating factor (G-CSF) co-regulates oocyte maturation. • G-CSF influences embryonic development, implantation, and trophoblastic growth. • G-CSF seems to be beneficial in repetitive implantation failures (RIF). • G-CSF is beneficial for certain patients with recur...

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Veröffentlicht in:	Journal of reproductive immunology 2015-04, Vol.108, p.123-135
1. Verfasser:	Wuerfel, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Abortion, Spontaneous - immunology Animals Cell Differentiation Embryo Implantation Endometrium - immunology Female Granulocyte colony-stimulating factor (G-CSF) Granulocyte Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Humans Models, Animal Obstetrics and Gynecology Oocytes - physiology Recurrence Recurrent spontaneous abortion (RSA) Repetitive implantation failure (RIF) Reproductive Medicine - trends
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Beschreibung
Zusammenfassung:	Highlights • Granulocyte colony-stimulating factor (G-CSF) co-regulates oocyte maturation. • G-CSF influences embryonic development, implantation, and trophoblastic growth. • G-CSF seems to be beneficial in repetitive implantation failures (RIF). • G-CSF is beneficial for certain patients with recurrent spontaneous abortions (RSA). • At present, there is no increased risk of G-CSF application in RIF and RSA patients.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.01.010