Stimulation of the JAK/STAT pathway by LIF and OSM in the human granulosa cell line COV434

Highlights • The LIF and OSM receptor unit GP130 is constitutively expressed in the human granulosa cell line COV434. • STAT3 is also constitutively expressed. • LIF and OSM induce immediate STAT3(tyr705) phosphorylation. • LIF and OSM strongly upregulate SOCS3 mRNA expression. • 24 h of LIF stimula...

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Veröffentlicht in:	Journal of reproductive immunology 2015-04, Vol.108, p.48-55
Hauptverfasser:	Pastuschek, Jana, Poetzsch, Jenny, Morales-Prieto, Diana M, Schleußner, Ekkehard, Markert, Udo R, Georgiev, Georgi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Communication Cell Line COV434 cell line Cytokine Receptor gp130 - genetics Cytokine Receptor gp130 - metabolism Female Gene Expression Regulation, Developmental Granulosa cells Granulosa Cells - immunology Humans IL6-type cytokines JAK/STAT pathway Janus Kinases - metabolism Leukemia Inhibitory Factor - immunology LIF Molecular Chaperones - genetics Molecular Chaperones - metabolism Obstetrics and Gynecology Oncostatin M - immunology OSM Pregnancy Protein Inhibitors of Activated STAT - genetics Protein Inhibitors of Activated STAT - metabolism Signal Transduction - immunology STAT3 Transcription Factor - metabolism Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism
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Beschreibung
Zusammenfassung:	Highlights • The LIF and OSM receptor unit GP130 is constitutively expressed in the human granulosa cell line COV434. • STAT3 is also constitutively expressed. • LIF and OSM induce immediate STAT3(tyr705) phosphorylation. • LIF and OSM strongly upregulate SOCS3 mRNA expression. • 24 h of LIF stimulation induces GP130, STAT3, and PIAS3 mRNA upregulation.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.03.002