Altered nociception in mice with genetically induced hypoglutamatergic tone

Highlights • Hyposensitivity to nociceptive stimuli characterized heterozygous GLS1+/− male mice with CNS hypoglutamatergic tone. • GLS1+/−-associated hyposensitivity was noted with mechanical, thermal as well as inflammatory nociceptive stimuli. • GLS1+/−-associated changes in nociception closely r...

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Veröffentlicht in:	Neuroscience 2015-05, Vol.293, p.80-91
Hauptverfasser:	Kayser, V, Viguier, F, Melfort, M, Bourgoin, S, Hamon, M, Masson, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Animals Excitatory Amino Acid Antagonists - administration & dosage formalin Glutamates - metabolism Glutamates - physiology Glutaminase - genetics Hot Temperature Male memantine Memantine - administration & dosage Mice Mice, Inbred C57BL Mice, Transgenic morphine Morphine - administration & dosage Neurology Nociception - physiology nociceptive tests Phenotype phosphate-activated glutaminase type 1 Physical Stimulation Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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Zusammenfassung:	Highlights • Hyposensitivity to nociceptive stimuli characterized heterozygous GLS1+/− male mice with CNS hypoglutamatergic tone. • GLS1+/−-associated hyposensitivity was noted with mechanical, thermal as well as inflammatory nociceptive stimuli. • GLS1+/−-associated changes in nociception closely resembled those induced by memantine in wild-type mice. • Hypoglutamatergic tone in GLS1+/− mice and memantine in wild-type mice both enhanced morphine antinociceptive potency. • Downregulated NMDA receptor-mediated glutamatergic tone apparently underlay nociception changes in GLS1+/− mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.02.044