6-Hydroxydiscodermindole, a new discodermindole from the marine sponge Discodermia polydiscus

6-Hydroxydiscodermindole, a new discodermindole from the marine sponge Discodermia polydiscus

6-Hydroxydiscodermindole (2), a new discodermindole analogue, has been isolated from the deep-water marine sponge Discodermia polydiscus. It showed marginal in vitro cytotoxicity against cultured murine P388 leukemia cells. The isolation, structure elucidation and cytotoxicity of 6-hydroxydiscodermi...

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Veröffentlicht in:Pharmaceutical biology 2004-01, Vol.42 (1), p.59-61
Hauptverfasser: Cohen, J, Paul, G.K, Gunasekera, S.P, Longley, R.E, Pomponi, S.A
Format: Artikel
Sprache:eng
Schlagworte:
6-hydroxydiscodermindole
Biological and medical sciences
Cytotoxicity
Demospongia
Discodermia polydiscus
Discodermia polydiscus de Bocage
General pharmacology
Lithistida
Marine
marine sponge
Medical sciences
NMR data
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera
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Zusammenfassung:6-Hydroxydiscodermindole (2), a new discodermindole analogue, has been isolated from the deep-water marine sponge Discodermia polydiscus. It showed marginal in vitro cytotoxicity against cultured murine P388 leukemia cells. The isolation, structure elucidation and cytotoxicity of 6-hydroxydiscodermindole (2) is described.
ISSN:1388-0209
1744-5116
DOI:10.1080/13880200490505546