A naphthalimide-based [12]aneN3 compound as an effective and real-time fluorescence tracking non-viral gene vector

A novel bifunctional naphthalimide-based [12]aneN3 compound 1 was successfully applied as an effective non-viral gene vector in cancer cells, the fluorescence properties of 1 clearly demonstrated the process of cellular uptake, DNA translocation and release based on real-time fluorescence tracking.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-12, Vol.51 (93), p.16695-16698
Hauptverfasser:	Gao, Yong-Guang, Shi, You-Di, Zhang, Ying, Hu, Jing, Lu, Zhong-Lin, He, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor DNA - metabolism Fluorescence Gene Transfer Techniques Genetic Vectors - chemical synthesis Genetic Vectors - chemistry Genetic Vectors - metabolism Genetic Vectors - pharmacokinetics Humans Molecular Structure Naphthalimides - chemistry Naphthalimides - metabolism Naphthalimides - pharmacokinetics Time Factors
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Beschreibung
Zusammenfassung:	A novel bifunctional naphthalimide-based [12]aneN3 compound 1 was successfully applied as an effective non-viral gene vector in cancer cells, the fluorescence properties of 1 clearly demonstrated the process of cellular uptake, DNA translocation and release based on real-time fluorescence tracking.
ISSN:	1364-548X
DOI:	10.1039/c5cc06753g