More accurate measurement of vancomycin minimum inhibitory concentration indicates poor outcomes in meticillin-resistant Staphylococcus aureus bacteraemia

Highlights • We evaluated the effect of vancomycin (VAN) on MRSA bacteraemia prognosis. • A VAN MIC ≥1.5 μg/mL and Charlson co-morbidity index was related to mortality. • VAN therapy did not affect the clinical prognosis. • Strains with high a VAN MIC also had high teicoplanin (TEC) and daptomycin (...

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Veröffentlicht in:	International journal of antimicrobial agents 2015-11, Vol.46 (5), p.532-537
Hauptverfasser:	Shoji, Hisashi, Maeda, Masayuki, Shirakura, Tetsuro, Takuma, Takahiro, Ugajin, Kazuhisa, Fukuchi, Kunihiko, Ishino, Keiko, Niki, Yoshihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteraemia Bacteremia - drug therapy Bacteremia - microbiology Bacteremia - mortality Female Hospitals, University Humans Infectious Disease Linezolid Male Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - isolation & purification Meticillin-resistant Staphylococcus aureus Microbial Sensitivity Tests - methods Middle Aged Minimum inhibitory concentration MRSA Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Infections - mortality Survival Analysis Tokyo Treatment Outcome Vancomycin Vancomycin - pharmacology Vancomycin - therapeutic use
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Zusammenfassung:	Highlights • We evaluated the effect of vancomycin (VAN) on MRSA bacteraemia prognosis. • A VAN MIC ≥1.5 μg/mL and Charlson co-morbidity index was related to mortality. • VAN therapy did not affect the clinical prognosis. • Strains with high a VAN MIC also had high teicoplanin (TEC) and daptomycin (DAP) MICs. • TEC and DAP may not be used in patients with a high VAN MIC owing to cross-resistance.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.07.013