Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage
Highlights • Three major clonal lineages (CC1, CC2 and CC149) were detected among multidrug-resistant (MDR) Acinetobacter baumannii isolates at a single institution. • The complete genome of one A. baumannii isolate belonging to the novel CC149 clonal lineage was sequenced. • These isolates containe...
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| Veröffentlicht in: | International journal of antimicrobial agents 2015-11, Vol.46 (5), p.526-531 |
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| creator | Shrestha, Shovita Tada, Tatsuya Miyoshi-Akiyama, Tohru Ohara, Hiroshi Shimada, Kayo Satou, Kazuhito Teruya, Kuniko Nakano, Kazuma Shiroma, Akino Sherchand, Jeevan Bdr Rijal, Basista Psd Hirano, Takashi Kirikae, Teruo Pokhrel, Bharat Mani |
| description | Highlights • Three major clonal lineages (CC1, CC2 and CC149) were detected among multidrug-resistant (MDR) Acinetobacter baumannii isolates at a single institution. • The complete genome of one A. baumannii isolate belonging to the novel CC149 clonal lineage was sequenced. • These isolates contained NDM-1, OXA-23 or OXA-58 carbapenemases and 16S rRNA methylase ArmA. • MDR and extensively drug-resistant (XDR) susceptibility profiles were determined for these isolates. |
| doi_str_mv | 10.1016/j.ijantimicag.2015.07.012 |
| format | Article |
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| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2015-11, Vol.46 (5), p.526-531 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 16S rRNA methylase Acinetobacter baumannii - classification Acinetobacter baumannii - drug effects Acinetobacter baumannii - genetics Acinetobacter baumannii - isolation & purification Acinetobacter Infections - epidemiology Acinetobacter Infections - microbiology Anti-Bacterial Agents - pharmacology Carbapenemase Clonal complex Cross Infection - epidemiology Cross Infection - microbiology Disk Diffusion Antimicrobial Tests DNA, Bacterial - chemistry DNA, Bacterial - genetics Drug Resistance, Multiple, Bacterial Genome, Bacterial Genotype Hospitals, University Humans Infectious Disease Molecular Epidemiology Molecular Sequence Data Molecular Typing Multidrug-resistant Acinetobacter baumannii Nepal - epidemiology Sequence Analysis, DNA |
| title | Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage |
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