Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage

Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage

Highlights • Three major clonal lineages (CC1, CC2 and CC149) were detected among multidrug-resistant (MDR) Acinetobacter baumannii isolates at a single institution. • The complete genome of one A. baumannii isolate belonging to the novel CC149 clonal lineage was sequenced. • These isolates containe...

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Veröffentlicht in:International journal of antimicrobial agents 2015-11, Vol.46 (5), p.526-531
Hauptverfasser: Shrestha, Shovita, Tada, Tatsuya, Miyoshi-Akiyama, Tohru, Ohara, Hiroshi, Shimada, Kayo, Satou, Kazuhito, Teruya, Kuniko, Nakano, Kazuma, Shiroma, Akino, Sherchand, Jeevan Bdr, Rijal, Basista Psd, Hirano, Takashi, Kirikae, Teruo, Pokhrel, Bharat Mani
Format: Artikel
Sprache:eng
Schlagworte:
16S rRNA methylase
Acinetobacter baumannii - classification
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - epidemiology
Acinetobacter Infections - microbiology
Anti-Bacterial Agents - pharmacology
Carbapenemase
Clonal complex
Cross Infection - epidemiology
Cross Infection - microbiology
Disk Diffusion Antimicrobial Tests
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Drug Resistance, Multiple, Bacterial
Genome, Bacterial
Genotype
Hospitals, University
Humans
Infectious Disease
Molecular Epidemiology
Molecular Sequence Data
Molecular Typing
Multidrug-resistant Acinetobacter baumannii
Nepal - epidemiology
Sequence Analysis, DNA
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Zusammenfassung:Highlights • Three major clonal lineages (CC1, CC2 and CC149) were detected among multidrug-resistant (MDR) Acinetobacter baumannii isolates at a single institution. • The complete genome of one A. baumannii isolate belonging to the novel CC149 clonal lineage was sequenced. • These isolates contained NDM-1, OXA-23 or OXA-58 carbapenemases and 16S rRNA methylase ArmA. • MDR and extensively drug-resistant (XDR) susceptibility profiles were determined for these isolates.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.07.012