Inhibitor recurrence after immune tolerance induction: a multicenter retrospective cohort study

Summary Background Immune tolerance induction (ITI) in patients with congenital hemophilia A is successful in up to 70%. Although there is growing understanding of predictors of response to ITI, the probability and predictors of inhibitor recurrence after successful ITI are not well understood. Obje...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2015-11, Vol.13 (11), p.1980-1988
Hauptverfasser:	Antun, A., Monahan, P. E., Manco‐Johnson, M. J., Callaghan, M. U., Kanin, M., Knoll, C., Carpenter, S. L., Davis, J. A., Guerrera, M. F., Kruse‐Jarres, R., Ragni, M. V., Witmer, C., McCracken, C. E., Kempton, C. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Child, Preschool Confidence intervals Factor VIII - administration & dosage Factor VIII - immunology Factor VIII - therapeutic use Female hemophilia Hemophilia A - drug therapy Hemophilia A - immunology Humans immune tolerance Immunosuppression Immunosuppressive Agents - therapeutic use incidence Infant Isoantibodies - biosynthesis Isoantibodies - blood Isoantibodies - immunology Kaplan-Meier Estimate Logistic Models Male Medication Adherence Models, Immunological Plasmapheresis Propensity Score prophylaxis Recombinant Proteins - immunology Recombinant Proteins - therapeutic use Recurrence Retrospective Studies Time Factors
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Zusammenfassung:	Summary Background Immune tolerance induction (ITI) in patients with congenital hemophilia A is successful in up to 70%. Although there is growing understanding of predictors of response to ITI, the probability and predictors of inhibitor recurrence after successful ITI are not well understood. Objectives To determine the association of clinical characteristics, particularly adherence to factor VIII (FVIII) prophylaxis after ITI, with inhibitor recurrence in patients with hemophilia A who were considered tolerant after ITI. Methods In this multicenter retrospective cohort study, 64 subjects with FVIII level
ISSN:	1538-7933 1538-7836 1538-7836
DOI:	10.1111/jth.13143