Preoperative low serum testosterone is associated with high-grade prostate cancer and an increased Gleason score upgrading

Background: To compare histological feature of prostate cancer (PCa) according androgenic status in patients who underwent radical prostatectomy (RP). Methods: Between March 2007 and September 2013, we prospectively analysed 937 patients who were referred to our centre for RP. Clinical, pathological...

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Veröffentlicht in:	Prostate cancer and prostatic diseases 2015-12, Vol.18 (4), p.382-387
Hauptverfasser:	Pichon, A, Neuzillet, Y, Botto, H, Raynaud, J-P, Radulescu, C, Molinié, V, Herve, J-M, Lebret, T
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/409 692/699 Adult Aged Bioavailability Biomedical and Life Sciences Biomedicine Biopsy Biopsy, Needle Cancer Research Cancer surgery Care and treatment Comorbidity Complications and side effects France - epidemiology Humans Influence Male Meta-analysis Middle Aged Neoplasm Grading Neoplasm Staging Odds Ratio original-article Preoperative Period Prostate cancer Prostatectomy Prostatic Neoplasms - blood Prostatic Neoplasms - epidemiology Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Risk analysis Risk Factors Testosterone Testosterone - blood Urological surgery
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Zusammenfassung:	Background: To compare histological feature of prostate cancer (PCa) according androgenic status in patients who underwent radical prostatectomy (RP). Methods: Between March 2007 and September 2013, we prospectively analysed 937 patients who were referred to our centre for RP. Clinical, pathological and biological data have been prospectively collected. Preoperative total testosterone (TT) and bioavailable testosterone (BT) serum determinations were carried out. The threshold for low serum testosterone was set at TT
ISSN:	1365-7852 1476-5608
DOI:	10.1038/pcan.2015.44