Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study
Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to...
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| Veröffentlicht in: | Clinical colorectal cancer 2015-12, Vol.14 (4), p.291-295 |
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| container_title | Clinical colorectal cancer |
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| creator | Armstrong, Dawn Raissouni, Soundouss Price Hiller, Julie Mercer, Jamison Powell, Erin MacLean, Anthony Jiang, Maria Doll, Corinne Goodwin, Rachel Batuyong, Eugene Zhou, Kevin Monzon, Jose G Tang, Patricia A Heng, Daniel Y Cheung, Winson Y Vickers, Michael M |
| description | Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR. |
| doi_str_mv | 10.1016/j.clcc.2015.06.001 |
| format | Article |
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To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR.</description><identifier>ISSN: 1533-0028</identifier><identifier>EISSN: 1938-0674</identifier><identifier>DOI: 10.1016/j.clcc.2015.06.001</identifier><identifier>PMID: 26433487</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Canada ; Carcinoembryonic Antigen - blood ; Carcinoembryonic antigen level ; Chemoradiotherapy - methods ; Disease-Free Survival ; Gastroenterology and Hepatology ; Hematology, Oncology and Palliative Medicine ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Middle Aged ; Neoadjuvant chemoradiation ; Neoadjuvant Therapy - methods ; Pathologic response ; Predictive factors ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Retrospective Studies ; Statin ; Survival Rate ; Treatment Outcome</subject><ispartof>Clinical colorectal cancer, 2015-12, Vol.14 (4), p.291-295</ispartof><rights>2015</rights><rights>Crown Copyright © 2015. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-75d6b213aa588cd31fc2a111aeae2ea5f089b69363a4da4f664d704e44ffaa123</citedby><cites>FETCH-LOGICAL-c547t-75d6b213aa588cd31fc2a111aeae2ea5f089b69363a4da4f664d704e44ffaa123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1533002815000730$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26433487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, Dawn</creatorcontrib><creatorcontrib>Raissouni, Soundouss</creatorcontrib><creatorcontrib>Price Hiller, Julie</creatorcontrib><creatorcontrib>Mercer, Jamison</creatorcontrib><creatorcontrib>Powell, Erin</creatorcontrib><creatorcontrib>MacLean, Anthony</creatorcontrib><creatorcontrib>Jiang, Maria</creatorcontrib><creatorcontrib>Doll, Corinne</creatorcontrib><creatorcontrib>Goodwin, Rachel</creatorcontrib><creatorcontrib>Batuyong, Eugene</creatorcontrib><creatorcontrib>Zhou, Kevin</creatorcontrib><creatorcontrib>Monzon, Jose G</creatorcontrib><creatorcontrib>Tang, Patricia A</creatorcontrib><creatorcontrib>Heng, Daniel Y</creatorcontrib><creatorcontrib>Cheung, Winson Y</creatorcontrib><creatorcontrib>Vickers, Michael M</creatorcontrib><title>Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study</title><title>Clinical colorectal cancer</title><addtitle>Clin Colorectal Cancer</addtitle><description>Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR.</description><subject>Canada</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Carcinoembryonic antigen level</subject><subject>Chemoradiotherapy - methods</subject><subject>Disease-Free Survival</subject><subject>Gastroenterology and Hepatology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Middle Aged</subject><subject>Neoadjuvant chemoradiation</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Pathologic response</subject><subject>Predictive factors</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Retrospective Studies</subject><subject>Statin</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1533-0028</issn><issn>1938-0674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1v1DAQxSMEoqXwD3BAPnJJ8FecLEJIqxVfUoGKlrM1a0_AwYm3tlNp_3scbeHAgdM8ad570vymqp4z2jDK1KuxMd6YhlPWNlQ1lLIH1TnbiL6mqpMPi26FqCnl_Vn1JKWxKCUYe1ydcSWFkH13Xk1XEa0zOcREwkCuIP8MPvxwhuzCdPCYkXzDdAhzQrIdMkbyBQPYcbmDOZObiJAnLGoIsRhNBk92MBuMr8mWfF58dqasS-w6L_b4tHo0gE_47H5eVN_fv7vZfawvv374tNte1qaVXa671qo9ZwKg7XtjBRsMB8YYICBHaAfab_ZqI5QAaUEOSknbUYlSDgMA4-KiennqPcRwu2DKenLJoPcwY1iSZp3ggnZSboqVn6wmhpQiDvoQ3QTxqBnVK2Y96hWzXjFrqnTBXEIv7vuX_YT2b-QP12J4czJgufLOYdTJOCxcrIuFkrbB_b__7T9x493sDPhfeMQ0hiXOhZ9mOnFN9fX66PXPrKWUdoKK37-Bo-4</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Armstrong, Dawn</creator><creator>Raissouni, Soundouss</creator><creator>Price Hiller, Julie</creator><creator>Mercer, Jamison</creator><creator>Powell, Erin</creator><creator>MacLean, Anthony</creator><creator>Jiang, Maria</creator><creator>Doll, Corinne</creator><creator>Goodwin, Rachel</creator><creator>Batuyong, Eugene</creator><creator>Zhou, Kevin</creator><creator>Monzon, Jose G</creator><creator>Tang, Patricia A</creator><creator>Heng, Daniel Y</creator><creator>Cheung, Winson Y</creator><creator>Vickers, Michael M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151201</creationdate><title>Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study</title><author>Armstrong, Dawn ; Raissouni, Soundouss ; Price Hiller, Julie ; Mercer, Jamison ; Powell, Erin ; MacLean, Anthony ; Jiang, Maria ; Doll, Corinne ; Goodwin, Rachel ; Batuyong, Eugene ; Zhou, Kevin ; Monzon, Jose G ; Tang, Patricia A ; Heng, Daniel Y ; Cheung, Winson Y ; Vickers, Michael M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-75d6b213aa588cd31fc2a111aeae2ea5f089b69363a4da4f664d704e44ffaa123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Canada</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Carcinoembryonic antigen level</topic><topic>Chemoradiotherapy - methods</topic><topic>Disease-Free Survival</topic><topic>Gastroenterology and Hepatology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Middle Aged</topic><topic>Neoadjuvant chemoradiation</topic><topic>Neoadjuvant Therapy - methods</topic><topic>Pathologic response</topic><topic>Predictive factors</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Retrospective Studies</topic><topic>Statin</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armstrong, Dawn</creatorcontrib><creatorcontrib>Raissouni, Soundouss</creatorcontrib><creatorcontrib>Price Hiller, Julie</creatorcontrib><creatorcontrib>Mercer, Jamison</creatorcontrib><creatorcontrib>Powell, Erin</creatorcontrib><creatorcontrib>MacLean, Anthony</creatorcontrib><creatorcontrib>Jiang, Maria</creatorcontrib><creatorcontrib>Doll, Corinne</creatorcontrib><creatorcontrib>Goodwin, Rachel</creatorcontrib><creatorcontrib>Batuyong, Eugene</creatorcontrib><creatorcontrib>Zhou, Kevin</creatorcontrib><creatorcontrib>Monzon, Jose G</creatorcontrib><creatorcontrib>Tang, Patricia A</creatorcontrib><creatorcontrib>Heng, Daniel Y</creatorcontrib><creatorcontrib>Cheung, Winson Y</creatorcontrib><creatorcontrib>Vickers, Michael M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical colorectal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, Dawn</au><au>Raissouni, Soundouss</au><au>Price Hiller, Julie</au><au>Mercer, Jamison</au><au>Powell, Erin</au><au>MacLean, Anthony</au><au>Jiang, Maria</au><au>Doll, Corinne</au><au>Goodwin, Rachel</au><au>Batuyong, Eugene</au><au>Zhou, Kevin</au><au>Monzon, Jose G</au><au>Tang, Patricia A</au><au>Heng, Daniel Y</au><au>Cheung, Winson Y</au><au>Vickers, Michael M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study</atitle><jtitle>Clinical colorectal cancer</jtitle><addtitle>Clin Colorectal Cancer</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>14</volume><issue>4</issue><spage>291</spage><epage>295</epage><pages>291-295</pages><issn>1533-0028</issn><eissn>1938-0674</eissn><abstract>Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26433487</pmid><doi>10.1016/j.clcc.2015.06.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Canada Carcinoembryonic Antigen - blood Carcinoembryonic antigen level Chemoradiotherapy - methods Disease-Free Survival Gastroenterology and Hepatology Hematology, Oncology and Palliative Medicine Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Middle Aged Neoadjuvant chemoradiation Neoadjuvant Therapy - methods Pathologic response Predictive factors Rectal Neoplasms - pathology Rectal Neoplasms - therapy Retrospective Studies Statin Survival Rate Treatment Outcome |
| title | Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study |
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