Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study

Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to...

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Veröffentlicht in:	Clinical colorectal cancer 2015-12, Vol.14 (4), p.291-295
Hauptverfasser:	Armstrong, Dawn, Raissouni, Soundouss, Price Hiller, Julie, Mercer, Jamison, Powell, Erin, MacLean, Anthony, Jiang, Maria, Doll, Corinne, Goodwin, Rachel, Batuyong, Eugene, Zhou, Kevin, Monzon, Jose G, Tang, Patricia A, Heng, Daniel Y, Cheung, Winson Y, Vickers, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Canada Carcinoembryonic Antigen - blood Carcinoembryonic antigen level Chemoradiotherapy - methods Disease-Free Survival Gastroenterology and Hepatology Hematology, Oncology and Palliative Medicine Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Middle Aged Neoadjuvant chemoradiation Neoadjuvant Therapy - methods Pathologic response Predictive factors Rectal Neoplasms - pathology Rectal Neoplasms - therapy Retrospective Studies Statin Survival Rate Treatment Outcome
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Zusammenfassung:	Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR.
ISSN:	1533-0028 1938-0674
DOI:	10.1016/j.clcc.2015.06.001