Screening of Microbial Products Modifying the Action of Leptin (Obese Gene Product) by a Biosensor

Leptin is the ob gene product synthesized in adipose tissue and plays an important role in body weight homeostasis and reproduction. In the purpose of getting tools for understanding leptin's biological actions, low molecular weight microbial metabolites, which interact with leptin, were screen...

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Veröffentlicht in:	Journal of antibiotics 1999/04/25, Vol.52(4), pp.429-432
Hauptverfasser:	HIDAKA, TOMOMI, MORISHITA, TAKEHIKO, SHIMOTOHNO, KUMIKO W., ENDO, TOYOSHIGE, SETO, HARUO, NOGUCHI, TADASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - chemistry Biosensing Techniques Brain - metabolism Carrier Proteins - genetics Chaetomium Chaetomium - metabolism DNA, Complementary - metabolism Fatty Acids - chemistry Leptin Linoleic Acid - chemistry Magnetic Resonance Spectroscopy Oleic Acid - chemistry Palmitic Acid - chemistry Proteins - chemistry Proteins - drug effects Proteins - metabolism Rats Receptors, Cell Surface Receptors, Leptin Spectrometry, Mass, Fast Atom Bombardment Stearic Acids - chemistry
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Beschreibung
Zusammenfassung:	Leptin is the ob gene product synthesized in adipose tissue and plays an important role in body weight homeostasis and reproduction. In the purpose of getting tools for understanding leptin's biological actions, low molecular weight microbial metabolites, which interact with leptin, were screened using a BIAcore instrument (BIAcore1.000, Biacore), the surface plasmon resonance sensor. As a result of this screening, a fungus identified as Chaetomium sp. HB10 was found to produce an active substance.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.52.429