Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium

Abstract Objectives The clinical translation of cell-based therapies for ischemic heart disease has been limited because of low cell retention (

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2015-11, Vol.150 (5), p.1268-1277
Hauptverfasser:	Gaffey, Ann C., MD, Chen, Minna H., BChE, Venkataraman, Chantel M., BA, Trubelja, Alen, BS, Rodell, Christopher B., MS, Dinh, Patrick V, Hung, George, BA, MacArthur, John W., MD, Soopan, Renganaden V., MD, Burdick, Jason A., PhD, Atluri, Pavan, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Cyclodextrins - chemistry Cardiothoracic Surgery Cell Movement Cell Survival Cells, Cultured cellular therapy Disease Models, Animal Echocardiography, Doppler Endothelial Progenitor Cells - metabolism Endothelial Progenitor Cells - transplantation Fibrosis Genes, Reporter Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Hyaluronic Acid - chemistry hydrogel Hydrogels ischemic myocardium Male Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Myocardial Ischemia - physiopathology Myocardial Ischemia - surgery Myocardium - metabolism Myocardium - pathology Neovascularization, Physiologic Rats, Wistar Recovery of Function Regeneration shear-thinning gel Time Factors Tissue Scaffolds Transfection Ventricular Function, Left Ventricular Pressure Ventricular Remodeling
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Beschreibung
Zusammenfassung:	Abstract Objectives The clinical translation of cell-based therapies for ischemic heart disease has been limited because of low cell retention (
ISSN:	0022-5223 1097-685X
DOI:	10.1016/j.jtcvs.2015.07.035