Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone

Highlights • We investigated putative prosocial, mood altering and neuroendocrine effects of GHB in healthy males. • We found prosocial effects of GHB. • We found mood enhancing effects of GHB. • We found increased progesterone plasma levels after GHB intake. • Oxytocin and testosterone plasma level...

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Veröffentlicht in:	Psychoneuroendocrinology 2015-12, Vol.62, p.1-10
Hauptverfasser:	Bosch, Oliver G, Eisenegger, Christoph, Gertsch, Jürg, von Rotz, Robin, Dornbierer, Dario, Gachet, M. Salomé, Heinrichs, Markus, Wetter, Thomas C, Seifritz, Erich, Quednow, Boris B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adult Affect - drug effects Aldosterone - blood Altruism Brain - drug effects Club drug Cross-Over Studies Dehydroepiandrosterone - blood Emotions - drug effects Endocrinology & Metabolism Fairness Gamma-hydroxybutyric acid Humans Hydrocortisone - blood Hydroxybutyrates - pharmacology Male Oxytocin - blood Progesterone - blood Psychiatry Rape drug Social Behavior Sodium oxybate Testosterone - blood Young Adult
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Zusammenfassung:	Highlights • We investigated putative prosocial, mood altering and neuroendocrine effects of GHB in healthy males. • We found prosocial effects of GHB. • We found mood enhancing effects of GHB. • We found increased progesterone plasma levels after GHB intake. • Oxytocin and testosterone plasma levels, as well as HPA axis activity remained unaffected after GHB intake.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2015.07.167