Effect of pulmonary vascular resistance before left ventricular assist device implantation on short- and long-term post-transplant survival

Abstract Objectives Pulmonary hypertension is often considered a contraindication to orthotopic heart transplantation. Left ventricular assist device support may improve pulmonary hypertension by unloading the left ventricle, making patients eligible for transplantation. We sought to investigate the...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2015-11, Vol.150 (5), p.1352-1361.e2
Hauptverfasser:	Tsukashita, Masaki, MD, PhD, Takayama, Hiroo, MD, PhD, Takeda, Koji, MD, PhD, Han, Jiho, BS, Colombo, Paolo C., MD, Yuzefpolskaya, Melana, MD, Topkara, Veli K., MD, Garan, Arthur Reshad, MD, Mancini, Donna M., MD, Kurlansky, Paul A., MD, Naka, Yoshifumi, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Academic Medical Centers Adult Aged Cardiac Catheterization Cardiothoracic Surgery Female Heart Failure - diagnosis Heart Failure - mortality Heart Failure - physiopathology Heart Failure - therapy heart transplantation Heart Transplantation - adverse effects Heart Transplantation - mortality Heart-Assist Devices Hospital Mortality Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - mortality Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - therapy Kaplan-Meier Estimate Male Middle Aged New York City Patient Selection Predictive Value of Tests Prosthesis Design Pulmonary Artery - physiopathology pulmonary hypertension Retrospective Studies Risk Assessment Risk Factors Time Factors Treatment Outcome Vascular Resistance ventricular assist device Ventricular Function, Left
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Zusammenfassung:	Abstract Objectives Pulmonary hypertension is often considered a contraindication to orthotopic heart transplantation. Left ventricular assist device support may improve pulmonary hypertension by unloading the left ventricle, making patients eligible for transplantation. We sought to investigate the effect of continuous-flow left ventricular assist device support on pulmonary hypertension and compare post-transplantation outcomes in patients with preexisting pulmonary hypertension. Methods Between March 2004 and December 2013, 256 potential orthotopic heart transplantation candidates underwent continuous-flow left ventricular assist device implantation at Columbia University. Preimplantation right heart catheterization data were available for 227 patients. Patients were divided into 2 groups on the basis of preimplantation pulmonary vascular resistance: low (
ISSN:	0022-5223 1097-685X
DOI:	10.1016/j.jtcvs.2015.07.012