The Mosaic of Rottlerin
The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a...
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| Veröffentlicht in: | Journal of organic chemistry 2015-11, Vol.80 (21), p.10668-10674 |
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| container_end_page | 10674 |
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| container_issue | 21 |
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| container_title | Journal of organic chemistry |
| container_volume | 80 |
| creator | Hong, Kenneth K. C Ball, Graham E Black, David StC Kumar, Naresh |
| description | The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst. |
| doi_str_mv | 10.1021/acs.joc.5b01827 |
| format | Article |
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Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.</description><subject>Acetophenones - chemical synthesis</subject><subject>Acetophenones - chemistry</subject><subject>Angiogenesis Inhibitors - chemistry</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Benzopyrans - chemical synthesis</subject><subject>Benzopyrans - chemistry</subject><subject>Catalysis</subject><subject>Chalcones - chemical synthesis</subject><subject>Chalcones - chemistry</subject><subject>Humans</subject><subject>Phosphorylation</subject><subject>Protein Kinase C-delta - chemistry</subject><subject>Protein Kinase C-delta - metabolism</subject><issn>0022-3263</issn><issn>1520-6904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEURYMotlbX3UmXgkz7kpdkZpZS6gdUBKnrkGQSnDJtajKz8N87Zao73-Ztzr1wDyFTCnMKjC60TfNtsHNhgBYsPyNjKhhksgR-TsYAjGXIJI7IVUpb6E8IcUlGTHImS5RjMt18utlrSLq2s-Bn76FtGxfr_TW58LpJ7ub0J-TjcbVZPmfrt6eX5cM604jYZogCQHuqtcmNRguVoVwWlHv0RpiC29KXFgRWUnBnK-Y41aKocu4Zk67ACbkbeg8xfHUutWpXJ-uaRu9d6JKiOdK84GV-RBcDamNIKTqvDrHe6fitKKijDdXbUL0NdbLRJ25P5Z3ZueqP_53fA_cDMCS7uO-3_lv3AyE9aDE</recordid><startdate>20151106</startdate><enddate>20151106</enddate><creator>Hong, Kenneth K. 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| ispartof | Journal of organic chemistry, 2015-11, Vol.80 (21), p.10668-10674 |
| issn | 0022-3263 1520-6904 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Acetophenones - chemical synthesis Acetophenones - chemistry Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Benzopyrans - chemical synthesis Benzopyrans - chemistry Catalysis Chalcones - chemical synthesis Chalcones - chemistry Humans Phosphorylation Protein Kinase C-delta - chemistry Protein Kinase C-delta - metabolism |
| title | The Mosaic of Rottlerin |
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