The Mosaic of Rottlerin

The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a...

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Veröffentlicht in:	Journal of organic chemistry 2015-11, Vol.80 (21), p.10668-10674
Hauptverfasser:	Hong, Kenneth K. C, Ball, Graham E, Black, David StC, Kumar, Naresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - chemical synthesis Acetophenones - chemistry Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Benzopyrans - chemical synthesis Benzopyrans - chemistry Catalysis Chalcones - chemical synthesis Chalcones - chemistry Humans Phosphorylation Protein Kinase C-delta - chemistry Protein Kinase C-delta - metabolism
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Beschreibung
Zusammenfassung:	The first total synthesis of rottlerin is described. The methodology allows the development of potential novel protein kinase C δ (PKCδ) analogues for better treatment of various diseases. Kamalachalcone A and dimeric rottlerin were synthesized in a very practical and economical way using FeCl3 as a catalyst.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/acs.joc.5b01827