Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5

Glucocorticoids (GCs) affect the proliferation of growth plate chondrocytes. In this study, we investigated the role of the GC-inducible promyelocytic leukemia zinc finger (PLZF) gene in chondrocyte differentiation by using the chondrogenic cell line ATDC5. PLZF overexpression suppressed cell cycle...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-12, Vol.417, p.114-123
Hauptverfasser:	Naito, Masako, Vongsa, Souksavanh, Tsukune, Naoya, Ohashi, Akiko, Takahashi, Tomihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Animals CDK inhibitor Cell cycle Cell Cycle Checkpoints - drug effects Cell Differentiation - drug effects Cell Line Chondrocyte differentiation Chondrocytes - cytology Chondrocytes - drug effects Cyclin-Dependent Kinase Inhibitor p21 - genetics Dexamethasone - pharmacology Gene Expression Regulation - drug effects Glucocorticoid Glucocorticoids - pharmacology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice PLZF Promyelocytic Leukemia Zinc Finger Protein
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Zusammenfassung:	Glucocorticoids (GCs) affect the proliferation of growth plate chondrocytes. In this study, we investigated the role of the GC-inducible promyelocytic leukemia zinc finger (PLZF) gene in chondrocyte differentiation by using the chondrogenic cell line ATDC5. PLZF overexpression suppressed cell cycle progression (p
ISSN:	0303-7207 1872-8057
DOI:	10.1016/j.mce.2015.09.026