A case of sudden cardiac death following Domperidone self-medication

Highlights • Domperidone is used for gastroesophageal reflux and functional dyspepsia. • Domperidone is also used as an off-label drug for stimulating lactation. • Domperidone is available as an over-the-counter (OTC) drug in many countries. • Its therapeutic window is narrow (safety index of only 2...

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Veröffentlicht in:	Forensic science international 2015-09, Vol.254, p.e1-e3
Hauptverfasser:	Fais, Paolo, Vermiglio, Elisa, Laposata, Chiara, Lockwood, Robert, Gottardo, Rossella, De Leo, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcoholism - complications Arrhythmias, Cardiac - chemically induced Autopsy Breastfeeding & lactation China Criminal investigations Data processing Death Death, Sudden, Cardiac - etiology Domperidone Domperidone - adverse effects Domperidone - blood Drug dosages Drugs Edema Female Forensic science Forensic sciences Gastrointestinal Agents - adverse effects Gastrointestinal Agents - blood Humans Intervals Legal medicine Liver Liver Cirrhosis - complications Long QT Metabolism Middle Aged Mitral Valve Prolapse - complications Nitrogen Nonprescription Drugs Pathology Prolongation Risk Self Medication - adverse effects Self-medication Sudden cardiac death Urine Valves
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Zusammenfassung:	Highlights • Domperidone is used for gastroesophageal reflux and functional dyspepsia. • Domperidone is also used as an off-label drug for stimulating lactation. • Domperidone is available as an over-the-counter (OTC) drug in many countries. • Its therapeutic window is narrow (safety index of only 2.5). • Its administration is related to an increased risk of sudden cardiac death.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2015.06.004