A BODIPY-based 'turn-on' fluorescent probe for hypoxic cell imaging

A BODIPY-based 'turn-on' fluorescent probe for hypoxic cell imaging

A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a 'turn-on' fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (69), p.13389-13392
Hauptverfasser: Wang, Sisi, Liu, Hui, Mack, John, Tian, Jiangwei, Zou, Bin, Lu, Hua, Li, Zhifang, Jiang, Jianxiong, Shen, Zhen
Format: Artikel
Sprache:eng
Schlagworte:
Boron Compounds - chemistry
Crystallography, X-Ray
Decay
Dyes
Electrons
Fluorescence
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Imaging
Microscopy, Confocal
Molecular Conformation
Quantum Theory
Recovery
Reduction
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Beschreibung
Zusammenfassung:A boron-dipyrromethene (BODIPY) dye containing a styryl substituent with a hydroxyl and nitro group, 1a, exhibits a 'turn-on' fluorescence response for hypoxic cells. The presence of the electron-withdrawing nitro group results in a highly efficient nonradiative decay of the S1 state, and hence a recovery of fluorescence intensity when nitro reduction occurs under hypoxic conditions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05139h