Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-ones using oxygen as the oxidant

Palladium-catalyzed direct alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-ones using oxygen as the oxidant

A direct C-3 alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-ones through palladium-catalyzed C-H activation using oxygen as the terminal oxidant has been developed. This method provides an easy access to functionalized new 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-one derivatives.

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Bibliographische Detailangaben
Veröffentlicht in:RSC advances 2015-04, Vol.5 (46), p.36171-36174
Hauptverfasser: Lv, Junliang, Liang, Ying, He, Peiling, Cai, Zhihao, Liu, Jianwen, Huang, Fengxi
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Derivatives
Oxidants
Oxidizing agents
Terminals
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Zusammenfassung:A direct C-3 alkenylation of 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-ones through palladium-catalyzed C-H activation using oxygen as the terminal oxidant has been developed. This method provides an easy access to functionalized new 2-methyl-4H-pyrido[1,2-a]pyrimidi n-4-one derivatives.
ISSN:2046-2069
DOI:10.1039/c5ra02932e