Disruption of Ion Homeostasis by Verrucosin and a Related Compound

Disruption of Ion Homeostasis by Verrucosin and a Related Compound

We have found that (−)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testin...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2011, Vol.75 (5), p.1000-1002
Hauptverfasser: AKIYAMA, Koichi, TONE, Junichi, YAMAUCHI, Satoshi, SUGAHARA, Takuya, MARUYAMA, Masafumi, KAKINUMA, Yoshimi
Format: Artikel
Sprache:eng
Schlagworte:
Acridine Orange - metabolism
Biochemistry
Biological
Biotechnology
Cell Line, Tumor
Cellular
Disruption
Efflux
Furans - chemistry
Furans - pharmacology
Homeostasis
Homeostasis - drug effects
Humans
ion homeostasis
ionophore
Ions - metabolism
lignan
Lignans - chemistry
Lignans - pharmacology
Oranges
verrucosin
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Beschreibung
Zusammenfassung:We have found that (−)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.
ISSN:0916-8451
1347-6947
1347-6947
DOI:10.1271/bbb.110004