Annealing regulates the performance of an electrospun poly(ε-caprolactone) membrane to accommodate tissue engineering

The profound effect of annealing on the electrospun poly( epsilon -caprolactone) scaffold is comprehensively investigated for the first time. Interestingly, after annealing at 42 degree C, the contact angle of the sample decreases from (133.39 plus or minus 3.20) to (124.11 plus or minus 2.08) degree , meanwhile the Young's modulus dramatically increases from 8.41 plus or minus 1.64 to 11.27 plus or minus 2.41 MPa, which is attributed to the improved crystallinity. The above results and additional excellent cellular proliferation demonstrate that the annealed matrix possesses better physical and biological performances as a tissue engineering scaffold.