Rapidly dissolving poly(vinyl alcohol)/cyclodextrin electrospun nanofibrous membranes

We electrospun supramolecular complexes of poly(vinyl alcohol) (PVA), hydroxypropyl- beta -cyclodextrin (HP beta CD), and a poorly water soluble model drug (ketoprofen) to produce moisture-sensitive fibers for potential sublingual drug delivery applications. Fast dissolving/disintegrating membranes are of particular importance in sublingual delivery of drugs and other functional moieties, and materials such as nanofibers with a high specific surface area may be well-suited for such applications. Surprisingly, the concentrations of PVA and HP beta CD required to produce uniform blend fibers are lower than the respective neat components. We find that PVA plays a synergistic role in facilitating fiber formation, enabling us to produce fibers with a high cyclodextrin (e.g. 90 wt%) content. We attribute the mechanism of fiber formation to the presence of HP beta CD aggregates and PVA chain networks, analogous to depletion flocculation. Fibers with the highest HP beta CD content release the most drugs in the shortest amount of time, and the amount of drug loading and the dissolution rate of the drug-containing fibers can be tuned by over two orders of magnitude by varying the HP beta CD/PVA ratio.