First example of a Prins–Ritter reaction on terpenoids: a diastereoselective route to novel 4-amido-octahydro-2H-chromenes

First example of a Prins–Ritter reaction on terpenoids: a diastereoselective route to novel 4-amido-octahydro-2H-chromenes

(-)-Isopulegol was subjected to a triflic acid-promoted three-component Prins-Ritter reaction with a series of aldehydes to produce a library of novel 4-acetamido-octahydro-2H-chromene derivatives in good yields and high diastereoselectivities.

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (43), p.22387-22397
Hauptverfasser: Sarmah, Barnali, Baishya, Gakul, Baruah, Rajani K.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Derivatives
Libraries
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Zusammenfassung:(-)-Isopulegol was subjected to a triflic acid-promoted three-component Prins-Ritter reaction with a series of aldehydes to produce a library of novel 4-acetamido-octahydro-2H-chromene derivatives in good yields and high diastereoselectivities.
ISSN:2046-2069
2046-2069
DOI:10.1039/c4ra02124j