Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh–TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity o...

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (86), p.46351-46356
Hauptverfasser: Shende, Vaishali S., Shingote, Savita K., Deshpande, Sudhindra H., Kuriakose, Nishamol, Vanka, Kumar, Kelkar, Ashutosh A.
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Catalysts
Hydrogen storage
Hydrogenation
Imines
Methyl alcohol
Productivity
Sodium
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Zusammenfassung:Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh–TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity of the reaction was investigated by DFT. The mechanism for ATH of the imines has been discussed on the basis of the DFT study.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA07964G