Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

Lysosomes are promising targets for cancer and enzyme replacement therapy. In this area of interest we present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of confocal and fluorescence microscopy measurements...

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (102), p.58204-58207
Hauptverfasser: Crucianelli, E., Bruni, P., Frontini, A., Massaccesi, L., Pisani, M., Smorlesi, A., Mobbili, G.
Format: Artikel
Sprache:eng
Schlagworte:
Confocal
Conjugates
Fluorescence
Liposomes
Lysosomes
Mannose
Microscopy
Nanostructure
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Beschreibung
Zusammenfassung:Lysosomes are promising targets for cancer and enzyme replacement therapy. In this area of interest we present a novel liposomal nanocarrier containing mannose 6-phosphate-cholesteryl conjugates and show its ability to reach the lysosomes by means of confocal and fluorescence microscopy measurements.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA08681C