Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with...

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Veröffentlicht in:Trends in endocrinology and metabolism 2015-11, Vol.26 (11), p.592-594
Hauptverfasser: Feldman, Ross D, Limbird, Lee E
Format: Artikel
Sprache:eng
Schlagworte:
aldosterone
Aldosterone - metabolism
Endocrinology & Metabolism
estrogen
GPCR
GPER
Humans
Receptors, Estrogen - metabolism
Receptors, G-Protein-Coupled - metabolism
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Zusammenfassung:Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2015.09.002