Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells

Mitochondrial dysfunction in muscles leads to a wide range of metabolic and age-related disorders. Recently, it has been reported that a natural polyphenol, resveratrol, affects mitochondrial biogenesis. This study aimed to identify other natural polyphenolic compounds that regulate mitochondrial bi...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2015-11, Vol.26 (11), p.1193-1199
Hauptverfasser:	Yoshino, Makiko, Naka, Ayano, Sakamoto, Yuri, Shibasaki, Ayako, Toh, Mariko, Tsukamoto, Sakuka, Kondo, Kazuo, Iida, Kaoruko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cell Line Daidzein Dietary Supplements DNA-Binding Proteins - genetics Drug Evaluation, Preclinical - methods Gene Expression Regulation - drug effects High Mobility Group Proteins - genetics Isoflavones - pharmacology Mice Mitochondria Mitochondria, Muscle - drug effects Mitochondria, Muscle - genetics Mitochondria, Muscle - metabolism Muscles Myoblasts - drug effects Myoblasts - metabolism NF-E2-Related Factor 1 - metabolism Oxidative Phosphorylation - drug effects PGC1α Polyphenols - pharmacology Promoter Regions, Genetic - drug effects Sirtuin 1 - genetics Sirtuin 1 - metabolism Sirtuin-1
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