Predictive value of biomarkers for the prognosis of acute pulmonary embolism in Japanese patients: Results of the Tokyo CCU Network registry

Abstract Background Several studies from Western countries have reported associations between cardiac troponin and B-type natriuretic peptide (BNP) levels and acute pulmonary embolism prognosis; however, the number of such reports from Asian countries, including Japan, is limited. Thus, we evaluated the relationship between blood biochemical findings and acute-phase pulmonary embolism prognosis in Japanese patients. Methods The subjects included 441 patients with acute pulmonary embolism (191 men, 250 women; average age, 65.8 ± 16.0 years) treated at Tokyo CCU Network Institutions from 2009 to 2011 and registered via survey forms. The association between blood biochemical findings at admission and 30-day mortality was investigated. Results The median BNP value was 186.5 pg/mL (25th to 75th interquartile range: 49.8–500 pg/mL) of 210 cases. No deaths were recorded among those with BNP levels