The proenkephalin gene (PENK) and opioid dependence
WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 13...
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| Veröffentlicht in: | Neuroreport 1999-04, Vol.10 (5), p.1133-1135 |
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| container_title | Neuroreport |
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| creator | Comings, David E Blake, Hezekiah Dietz, George Gade-Andavolu, Radhika Legro, Richard S Saucier, Gerard Johnson, Patrick Verde, Ray MacMurray, James P |
| description | WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 132 controls. Among the subjects with opioid dependence, 66% carried the > 81 bp allele compared with 40% of subjects with other types of substance abuse (χ = 11.31, p < 0.004) and 49% of controls (χ = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence. |
| doi_str_mv | 10.1097/00001756-199904060-00042 |
| format | Article |
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Among the subjects with opioid dependence, 66% carried the > 81 bp allele compared with 40% of subjects with other types of substance abuse (χ = 11.31, p < 0.004) and 49% of controls (χ = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199904060-00042</identifier><identifier>PMID: 10321497</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Alcohol-Related Disorders - genetics ; Alleles ; Amphetamine-Related Disorders - genetics ; Biological and medical sciences ; Cocaine-Related Disorders - genetics ; Dinucleotide Repeats - genetics ; Drug addiction ; Enkephalins - genetics ; European Continental Ancestry Group - genetics ; Female ; Gene Frequency ; Heroin Dependence - genetics ; Humans ; Male ; Medical sciences ; Protein Precursors - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Among the subjects with opioid dependence, 66% carried the > 81 bp allele compared with 40% of subjects with other types of substance abuse (χ = 11.31, p < 0.004) and 49% of controls (χ = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcohol-Related Disorders - genetics</subject><subject>Alleles</subject><subject>Amphetamine-Related Disorders - genetics</subject><subject>Biological and medical sciences</subject><subject>Cocaine-Related Disorders - genetics</subject><subject>Dinucleotide Repeats - genetics</subject><subject>Drug addiction</subject><subject>Enkephalins - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Heroin Dependence - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Protein Precursors - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| fulltext | fulltext |
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| subjects | Addictive behaviors Adult Adult and adolescent clinical studies Alcohol-Related Disorders - genetics Alleles Amphetamine-Related Disorders - genetics Biological and medical sciences Cocaine-Related Disorders - genetics Dinucleotide Repeats - genetics Drug addiction Enkephalins - genetics European Continental Ancestry Group - genetics Female Gene Frequency Heroin Dependence - genetics Humans Male Medical sciences Protein Precursors - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Substance-Related Disorders - genetics |
| title | The proenkephalin gene (PENK) and opioid dependence |
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