The proenkephalin gene (PENK) and opioid dependence

WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 13...

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Veröffentlicht in:Neuroreport 1999-04, Vol.10 (5), p.1133-1135
Hauptverfasser: Comings, David E, Blake, Hezekiah, Dietz, George, Gade-Andavolu, Radhika, Legro, Richard S, Saucier, Gerard, Johnson, Patrick, Verde, Ray, MacMurray, James P
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Sprache:eng
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Zusammenfassung:WE tested the hypothesis that the alleles at the (CA)n repeat of the proenkephalin gene (PENK) might be associated with opioid addiction in 31 non-Hispanic Caucasian subjects with opioid dependence (heroin), 89 ethnically matched subjects with substance dependence other than opioid dependence and 132 controls. Among the subjects with opioid dependence, 66% carried the > 81 bp allele compared with 40% of subjects with other types of substance abuse (χ = 11.31, p < 0.004) and 49% of controls (χ = 6.0, p < 0.015). These results are consistent with a role of the PENK gene in opioid dependence.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199904060-00042