A simple effective method for estimating the [ 18O] enrichment of water mixtures

Isotopically enriched water, [ 18O] H 2O, recovered from the synthesis of [ 18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [ 16O] H 2O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [ 18O]...

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Veröffentlicht in:Applied radiation and isotopes 2004, Vol.60 (1), p.23-26
1. Verfasser: Fawdry, Richard M
Format: Artikel
Sprache:eng
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Zusammenfassung:Isotopically enriched water, [ 18O] H 2O, recovered from the synthesis of [ 18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [ 16O] H 2O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [ 18O] enrichment of water mixtures could aid PET cyclotron facilities to calculate the [ 18F] yields to be expected when the recovered [ 18O] H 2O is reused. A gravimetric method (repeatability for high enrichment ±0.3% [ 18O], detection limit ∼2% [ 18O] enrichment) is described.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2003.09.010