A simple effective method for estimating the [ 18O] enrichment of water mixtures
Isotopically enriched water, [ 18O] H 2O, recovered from the synthesis of [ 18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [ 16O] H 2O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [ 18O]...
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Veröffentlicht in: | Applied radiation and isotopes 2004, Vol.60 (1), p.23-26 |
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Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Isotopically enriched water, [
18O] H
2O, recovered from the synthesis of [
18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [
16O] H
2O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [
18O] enrichment of water mixtures could aid PET cyclotron facilities to calculate the [
18F] yields to be expected when the recovered [
18O] H
2O is reused. A gravimetric method (repeatability for high enrichment ±0.3% [
18O], detection limit ∼2% [
18O] enrichment) is described. |
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ISSN: | 0969-8043 1872-9800 |
DOI: | 10.1016/j.apradiso.2003.09.010 |