Watson–Crick hydrogen bonding of unlocked nucleic acids

Watson–Crick hydrogen bonding of unlocked nucleic acids

[Display omitted] We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of U...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2015-11, Vol.25 (22), p.5064-5066
Hauptverfasser: Langkjær, Niels, Wengel, Jesper, Pasternak, Anna
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine - analogs & derivatives
Adenosine - chemistry
Base Pairing
Base Sequence
Hydrogen Bonding
Inosine - chemistry
Nucleic Acid Conformation
Oligoribonucleotides - chemistry
RNA - chemistry
RNA duplex
RNA Stability
Thermodynamics
Unlocked nucleic acids
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Zusammenfassung:[Display omitted] We herein describe the synthesis of two new unlocked nucleic acid building blocks containing hypoxanthine and 2,6-diaminopurine as nucleobase moieties and their incorporation into oligonucleotides. The modified oligonucleotides were used to examine the thermodynamic properties of UNA against unmodified oligonucleotides and the resulting thermodynamic data support that the hydrogen bonding face of UNA is Watson–Crick like.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2015.10.024