Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction

Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction

A Pd-catalyzed highly enantio­selective three-component coupling of 1,3-dienes with aryl iodines and sodium dialkyl malonates has been successfully established by using a H8-BINOL-based phosphor­amidite ligand. This reaction proceeded via a Pd-catalyzed cascade aryl­ation and asymmetric allylic alky...

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Veröffentlicht in:Journal of the American Chemical Society 2015-10, Vol.137 (42), p.13476-13479
Hauptverfasser: Wu, Xiang, Lin, Hua-Chen, Li, Ming-Li, Li, Lu-Lu, Han, Zhi-Yong, Gong, Liu-Zhu
Format: Artikel
Sprache:eng
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Zusammenfassung:A Pd-catalyzed highly enantio­selective three-component coupling of 1,3-dienes with aryl iodines and sodium dialkyl malonates has been successfully established by using a H8-BINOL-based phosphor­amidite ligand. This reaction proceeded via a Pd-catalyzed cascade aryl­ation and asymmetric allylic alkyl­ation reaction, providing an efficient strategy for the enantio­selective 1,2-di­functional­ization of 1,3-dienes.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b08734