Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing
Synopsis Objective To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing. Methods A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face stu...
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| Veröffentlicht in: | International journal of cosmetic science 2015-12, Vol.37 (6), p.606-612 |
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| container_title | International journal of cosmetic science |
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| creator | Berardesca, E. Ardigo, M. Cameli, N. Mariano, M. Agozzino, M. Matts, P.J. |
| description | Synopsis
Objective
To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing.
Methods
A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face study among 40 female subjects aged 40–70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography.
Results
The GSS complex produced significant single‐variable (P |
| doi_str_mv | 10.1111/ics.12237 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1728258267</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3848602081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4617-7bd4bd0e5e89abbcf424f237d74f0d9d33d6c52ebb701ed8780aeb24066e23ae3</originalsourceid><addsrcrecordid>eNp1kd9u0zAUxiMEYmVwwQsgS9yARFbHceLkklWsG6qKtIK4tPznpPXqxMFOtpX35H1w220XSPjG8vHv-3yOvyR5m-GzLK6pUeEsIyRnz5JJRssqJbSmz5MJzihJC1rmJ8mrEG4wxrSu8pfJCSlqillRT5I_16LTrjW_QX9C2o3SQiqt6fT-fAsbo2JBuW7wztp9LfTWDGkjFKAwjHqHBofgVthRDICGDSBoGlBDQK6JV71RwiLRR5ESg3HdvizQ3FmNVsZu0Qq8UaabLo2Im2iNhunKrDsRewCkXNtbuEdRJ43rN7tw8OuFFy0M4APyYOPDet9F2JoOiTWYbv06edEIG-DNw36a_Lj48n12mS6-za9mnxepomXGUiY1lRpDAVUtpFQNJbSJ36gZbbCudZ7rUhUEpGQ4A12xCguQhOKyBJILyE-TD0ff3rtfI4SBtyYosFZ04MbAM0YqUlSkZBF9_w9640Yf5zxQrMxyhmmkPh4p5V0IHhree9MKv-MZ5vusecyaH7KO7LsHx1G2oJ_Ix3AjMD0Cd8bC7v9O_Gq2erRMjwoTBrh_Ugi_5XEEVvCfyzmvz68vl-dfK77I_wL-d8cn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1727613704</pqid></control><display><type>article</type><title>Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Berardesca, E. ; Ardigo, M. ; Cameli, N. ; Mariano, M. ; Agozzino, M. ; Matts, P.J.</creator><creatorcontrib>Berardesca, E. ; Ardigo, M. ; Cameli, N. ; Mariano, M. ; Agozzino, M. ; Matts, P.J.</creatorcontrib><description>Synopsis
Objective
To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing.
Methods
A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face study among 40 female subjects aged 40–70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography.
Results
The GSS complex produced significant single‐variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control.
Conclusion
The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
Résumé
Objectif
Pour étudier les effets de l'application topique d'un complexe de soie d'or séricine (GSS) sur les paramètres biophysiques liés au vieillissement de la peau.
Méthodes
Une gamme de méthodes de bio‐ingénierie non invasives a été déployée dans une étude randomisée sur huit semaines, en double aveugle, contre placebo, sur demi‐visage entre les 40 sujets féminins âgés de 40–70 ans. Les paramètres mesurés incluent un scorage expert de l'état de la peau, de la couche cornée (SC), de l'hydratation, la fonction de barrière SC, l'élasticité et la topographie de la surface.
Résultats
Le complexe GSS produit des améliorations significatives (P < 0.05, variable unique) dans le SC, l'hydratation, la fonction de barrière, l'élasticité et la topographie de la surface par rapport au témoin.
Conclusion
Le complexe GSS examiné dans la présente étude représente une nouvelle technologie topique esthétique intéressant pour aborder les multiples aspects de la peau âgée/photovieillie du visage féminin.</description><identifier>ISSN: 0142-5463</identifier><identifier>EISSN: 1468-2494</identifier><identifier>DOI: 10.1111/ics.12237</identifier><identifier>PMID: 25940759</identifier><identifier>CODEN: IJCMDW</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Administration, Topical ; Double-Blind Method ; hair + body care ; Humans ; Hydration ; moisturisation ; Niacinamide - administration & dosage ; Pharmaceutical Vehicles ; Sericins - administration & dosage ; Skin Aging - drug effects ; skin repair/acne/rosacea/dandruff/striae ; Topography</subject><ispartof>International journal of cosmetic science, 2015-12, Vol.37 (6), p.606-612</ispartof><rights>2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie</rights><rights>2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.</rights><rights>2015 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4617-7bd4bd0e5e89abbcf424f237d74f0d9d33d6c52ebb701ed8780aeb24066e23ae3</citedby><cites>FETCH-LOGICAL-c4617-7bd4bd0e5e89abbcf424f237d74f0d9d33d6c52ebb701ed8780aeb24066e23ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fics.12237$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fics.12237$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25940759$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berardesca, E.</creatorcontrib><creatorcontrib>Ardigo, M.</creatorcontrib><creatorcontrib>Cameli, N.</creatorcontrib><creatorcontrib>Mariano, M.</creatorcontrib><creatorcontrib>Agozzino, M.</creatorcontrib><creatorcontrib>Matts, P.J.</creatorcontrib><title>Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing</title><title>International journal of cosmetic science</title><addtitle>Int J Cosmet Sci</addtitle><description>Synopsis
Objective
To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing.
Methods
A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face study among 40 female subjects aged 40–70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography.
Results
The GSS complex produced significant single‐variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control.
Conclusion
The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
Résumé
Objectif
Pour étudier les effets de l'application topique d'un complexe de soie d'or séricine (GSS) sur les paramètres biophysiques liés au vieillissement de la peau.
Méthodes
Une gamme de méthodes de bio‐ingénierie non invasives a été déployée dans une étude randomisée sur huit semaines, en double aveugle, contre placebo, sur demi‐visage entre les 40 sujets féminins âgés de 40–70 ans. Les paramètres mesurés incluent un scorage expert de l'état de la peau, de la couche cornée (SC), de l'hydratation, la fonction de barrière SC, l'élasticité et la topographie de la surface.
Résultats
Le complexe GSS produit des améliorations significatives (P < 0.05, variable unique) dans le SC, l'hydratation, la fonction de barrière, l'élasticité et la topographie de la surface par rapport au témoin.
Conclusion
Le complexe GSS examiné dans la présente étude représente une nouvelle technologie topique esthétique intéressant pour aborder les multiples aspects de la peau âgée/photovieillie du visage féminin.</description><subject>Administration, Topical</subject><subject>Double-Blind Method</subject><subject>hair + body care</subject><subject>Humans</subject><subject>Hydration</subject><subject>moisturisation</subject><subject>Niacinamide - administration & dosage</subject><subject>Pharmaceutical Vehicles</subject><subject>Sericins - administration & dosage</subject><subject>Skin Aging - drug effects</subject><subject>skin repair/acne/rosacea/dandruff/striae</subject><subject>Topography</subject><issn>0142-5463</issn><issn>1468-2494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9u0zAUxiMEYmVwwQsgS9yARFbHceLkklWsG6qKtIK4tPznpPXqxMFOtpX35H1w220XSPjG8vHv-3yOvyR5m-GzLK6pUeEsIyRnz5JJRssqJbSmz5MJzihJC1rmJ8mrEG4wxrSu8pfJCSlqillRT5I_16LTrjW_QX9C2o3SQiqt6fT-fAsbo2JBuW7wztp9LfTWDGkjFKAwjHqHBofgVthRDICGDSBoGlBDQK6JV71RwiLRR5ESg3HdvizQ3FmNVsZu0Qq8UaabLo2Im2iNhunKrDsRewCkXNtbuEdRJ43rN7tw8OuFFy0M4APyYOPDet9F2JoOiTWYbv06edEIG-DNw36a_Lj48n12mS6-za9mnxepomXGUiY1lRpDAVUtpFQNJbSJ36gZbbCudZ7rUhUEpGQ4A12xCguQhOKyBJILyE-TD0ff3rtfI4SBtyYosFZ04MbAM0YqUlSkZBF9_w9640Yf5zxQrMxyhmmkPh4p5V0IHhree9MKv-MZ5vusecyaH7KO7LsHx1G2oJ_Ix3AjMD0Cd8bC7v9O_Gq2erRMjwoTBrh_Ugi_5XEEVvCfyzmvz68vl-dfK77I_wL-d8cn</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Berardesca, E.</creator><creator>Ardigo, M.</creator><creator>Cameli, N.</creator><creator>Mariano, M.</creator><creator>Agozzino, M.</creator><creator>Matts, P.J.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing</title><author>Berardesca, E. ; Ardigo, M. ; Cameli, N. ; Mariano, M. ; Agozzino, M. ; Matts, P.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4617-7bd4bd0e5e89abbcf424f237d74f0d9d33d6c52ebb701ed8780aeb24066e23ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Topical</topic><topic>Double-Blind Method</topic><topic>hair + body care</topic><topic>Humans</topic><topic>Hydration</topic><topic>moisturisation</topic><topic>Niacinamide - administration & dosage</topic><topic>Pharmaceutical Vehicles</topic><topic>Sericins - administration & dosage</topic><topic>Skin Aging - drug effects</topic><topic>skin repair/acne/rosacea/dandruff/striae</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berardesca, E.</creatorcontrib><creatorcontrib>Ardigo, M.</creatorcontrib><creatorcontrib>Cameli, N.</creatorcontrib><creatorcontrib>Mariano, M.</creatorcontrib><creatorcontrib>Agozzino, M.</creatorcontrib><creatorcontrib>Matts, P.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cosmetic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berardesca, E.</au><au>Ardigo, M.</au><au>Cameli, N.</au><au>Mariano, M.</au><au>Agozzino, M.</au><au>Matts, P.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing</atitle><jtitle>International journal of cosmetic science</jtitle><addtitle>Int J Cosmet Sci</addtitle><date>2015-12</date><risdate>2015</risdate><volume>37</volume><issue>6</issue><spage>606</spage><epage>612</epage><pages>606-612</pages><issn>0142-5463</issn><eissn>1468-2494</eissn><coden>IJCMDW</coden><abstract>Synopsis
Objective
To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing.
Methods
A range of non‐invasive bioengineering methods were deployed in an 8‐week randomized, double‐blinded, vehicle‐controlled, split‐face study among 40 female subjects aged 40–70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography.
Results
The GSS complex produced significant single‐variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control.
Conclusion
The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
Résumé
Objectif
Pour étudier les effets de l'application topique d'un complexe de soie d'or séricine (GSS) sur les paramètres biophysiques liés au vieillissement de la peau.
Méthodes
Une gamme de méthodes de bio‐ingénierie non invasives a été déployée dans une étude randomisée sur huit semaines, en double aveugle, contre placebo, sur demi‐visage entre les 40 sujets féminins âgés de 40–70 ans. Les paramètres mesurés incluent un scorage expert de l'état de la peau, de la couche cornée (SC), de l'hydratation, la fonction de barrière SC, l'élasticité et la topographie de la surface.
Résultats
Le complexe GSS produit des améliorations significatives (P < 0.05, variable unique) dans le SC, l'hydratation, la fonction de barrière, l'élasticité et la topographie de la surface par rapport au témoin.
Conclusion
Le complexe GSS examiné dans la présente étude représente une nouvelle technologie topique esthétique intéressant pour aborder les multiples aspects de la peau âgée/photovieillie du visage féminin.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25940759</pmid><doi>10.1111/ics.12237</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-5463 |
| ispartof | International journal of cosmetic science, 2015-12, Vol.37 (6), p.606-612 |
| issn | 0142-5463 1468-2494 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Administration, Topical Double-Blind Method hair + body care Humans Hydration moisturisation Niacinamide - administration & dosage Pharmaceutical Vehicles Sericins - administration & dosage Skin Aging - drug effects skin repair/acne/rosacea/dandruff/striae Topography |
| title | Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing |
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