Smoking-Induced Expression of the GPR15 Gene Indicates Its Potential Role in Chronic Inflammatory Pathologies

Despite the described clear epigenetic effects of smoking, the effect of smoking on genome-wide gene expression in the blood is obscure. We therefore studied the smoking-induced changes in the gene-expression profile of the peripheral blood. RNA was extracted from the whole blood of 48 individuals w...

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Veröffentlicht in:	The American journal of pathology 2015-11, Vol.185 (11), p.2898-2906
Hauptverfasser:	Kõks, Gea, Uudelepp, Mari-Liis, Limbach, Maia, Peterson, Pärt, Reimann, Ene, Kõks, Sulev
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cell Movement Chronic Disease Computational Biology DNA Methylation Female Gene Expression Regulation Gene Library Humans Immunity Inflammation - chemically induced Inflammation - genetics Inflammation - pathology Male Middle Aged Pathology Receptors, Formyl Peptide - drug effects Receptors, Formyl Peptide - genetics Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - genetics Receptors, Peptide - drug effects Receptors, Peptide - genetics Sequence Analysis, RNA Smoking - adverse effects Up-Regulation
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Zusammenfassung:	Despite the described clear epigenetic effects of smoking, the effect of smoking on genome-wide gene expression in the blood is obscure. We therefore studied the smoking-induced changes in the gene-expression profile of the peripheral blood. RNA was extracted from the whole blood of 48 individuals with a detailed smoking history (24 never-smokers, 16 smokers, and 8 ex-smokers). Gene-expression profiles were evaluated with RNA sequencing, and results were analyzed separately in 24 men and 24 women. In the male smokers, 13 genes were statistically significantly (false-discovery rate
ISSN:	0002-9440 1525-2191
DOI:	10.1016/j.ajpath.2015.07.006