Susceptibility-weighted imaging in acute-stage pediatric convulsive disorders

Background The aim of this preliminary study was to investigate the clinical use of acute‐stage susceptibility‐weighted imaging (SWI) in children with prolonged convulsive disorder. Methods Ten children with prolonged convulsive disorder who underwent SWI within 2 h after termination of seizure (acute‐stage SWI group) and 15 control children who underwent SWI > 2 h after their seizures terminated or for other purposes were enrolled. The cerebral venous vasculature was compared between the groups. The acute‐stage SWI group was further divided into three subgroups: normal group, those with regional low signals in the cerebral veins (regional group) and those with diffuse low signals in the cerebral veins (generalized group). Inter‐ictal electroencephalography (EEG) and venous blood gas findings during seizure activity were compared between these subgroups. Results All patients in the acute‐stage SWI group had low cerebral vein signal. Four patients were assigned to the regional group and six patients to the generalized group. Decrease of venous pH and the increase of venous pCO2 during seizure activity was more prominent in the regional group than in the generalized group. In the regional group, low‐signal areas in the cerebral veins were consistent with abnormal areas on EEG; these low‐signal areas resolved completely in all patients on follow‐up SWI. Ten patients in the control group had normal SWI, and five had a generalized low signal. Conclusions Acute‐stage SWI may be a useful alternative for identifying lateralization of seizures in children with prolonged convulsive disorder.