Effects of RHAMM/HMMR-Selective Peptides on Survival of Breast Cancer Cells

RHAMM-selective peptides in a concentration of 10 μg/ml (2×10 –7 M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h. Treatment of cancer cells with RHAMM-selective peptides induced apoptosis and necrosis and increased caspase-3 activity (by 30%).

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-09, Vol.159 (5), p.658-661
Hauptverfasser:	Akent’eva, N. P., Shushanov, S. S., Kotel’nikov, A. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Breast cancer Cancer cells Caspase 3 - genetics Caspase 3 - metabolism Cell Biology Cell Line Cell Line, Tumor Cell Survival - drug effects Extracellular Matrix Proteins - antagonists & inhibitors Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression - drug effects Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Hyaluronic acid Internal Medicine Laboratory Medicine Mice Mice, Knockout Molecular Sequence Data Necrosis - chemically induced Oxazines Pathology Peptides Peptides - chemical synthesis Peptides - pharmacology Xanthenes
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Beschreibung
Zusammenfassung:	RHAMM-selective peptides in a concentration of 10 μg/ml (2×10 –7 M) inhibited the growth of MDA-MB-231 breast cancer cells over 48 h. Treatment of cancer cells with RHAMM-selective peptides induced apoptosis and necrosis and increased caspase-3 activity (by 30%).
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-3041-3