Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study
Essential hypertension is an important risk factor for the development of cardiovascular disease. We aim in this study to analyse the relationship between AGT M235T gene variant and ACE I/D gene variant with essential hypertension in a sample of the Algerian population of the Oran city. A case-contr...
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| Veröffentlicht in: | Annales de biologie clinique (Paris) 2015-09, Vol.73 (5), p.557-563 |
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| creator | Amrani, Asma Baba Hamed, Mohamed Bey Mesli Talebbendiab, Farida |
| description | Essential hypertension is an important risk factor for the development of cardiovascular disease. We aim in this study to analyse the relationship between AGT M235T gene variant and ACE I/D gene variant with essential hypertension in a sample of the Algerian population of the Oran city. A case-control study has been performed in 145 subjects including; 75 hypertensives and 70 controls from Algerian population of Oran city. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the M235T variant of angiotensinogen (AGT) gene and a nested PCR to determine ACE I/D gene variant. The genotypic and allelic distribution of the M235Tvariant of the AGT gene did not differ in hypertensives and normotensives group (X(2) =7.81, P |
| doi_str_mv | 10.1684/abc.2015.1069 |
| format | Article |
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We aim in this study to analyse the relationship between AGT M235T gene variant and ACE I/D gene variant with essential hypertension in a sample of the Algerian population of the Oran city. A case-control study has been performed in 145 subjects including; 75 hypertensives and 70 controls from Algerian population of Oran city. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the M235T variant of angiotensinogen (AGT) gene and a nested PCR to determine ACE I/D gene variant. The genotypic and allelic distribution of the M235Tvariant of the AGT gene did not differ in hypertensives and normotensives group (X(2) =7.81, P<0.05; X(2) =4.67, respectively) thus there was no association between the T allele and hypertension (OR=1.64; 95%CI [1.01-2.69]). The genotypic and allelic frequencies of the ACE I/D variant did differ significantly between hypertensives and controls (X(2)=13.98, P<0.05; X(2) =12.66, P<0.05, respectively) where a significant association between the D allele of the ACE I/D gene and essential hypertension has been observed (OR=0.46; 95%CI [0.27-0.75]). We reported a high prevalence of the D and T allele in hypertensives female. This study shows that the M235T variant of the AGT gene is not associated with essential hypertension while a significant association has been reported with the D allele in this sample of Algerian population of the Oran city.</description><identifier>ISSN: 0003-3898</identifier><identifier>EISSN: 1950-6112</identifier><identifier>DOI: 10.1684/abc.2015.1069</identifier><identifier>PMID: 26489814</identifier><language>eng</language><publisher>France</publisher><subject>Adult ; Algeria ; Angiotensinogen - genetics ; Case-Control Studies ; Essential Hypertension ; Female ; Gene Frequency ; Genetics, Population ; Genotype ; Humans ; Hypertension - genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length</subject><ispartof>Annales de biologie clinique (Paris), 2015-09, Vol.73 (5), p.557-563</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-a922570bb546925af0f347a50359f4e816cae22eb53c74fcff4cf3706cde7b7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26489814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amrani, Asma</creatorcontrib><creatorcontrib>Baba Hamed, Mohamed Bey</creatorcontrib><creatorcontrib>Mesli Talebbendiab, Farida</creatorcontrib><title>Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study</title><title>Annales de biologie clinique (Paris)</title><addtitle>Ann Biol Clin (Paris)</addtitle><description>Essential hypertension is an important risk factor for the development of cardiovascular disease. We aim in this study to analyse the relationship between AGT M235T gene variant and ACE I/D gene variant with essential hypertension in a sample of the Algerian population of the Oran city. A case-control study has been performed in 145 subjects including; 75 hypertensives and 70 controls from Algerian population of Oran city. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the M235T variant of angiotensinogen (AGT) gene and a nested PCR to determine ACE I/D gene variant. The genotypic and allelic distribution of the M235Tvariant of the AGT gene did not differ in hypertensives and normotensives group (X(2) =7.81, P<0.05; X(2) =4.67, respectively) thus there was no association between the T allele and hypertension (OR=1.64; 95%CI [1.01-2.69]). The genotypic and allelic frequencies of the ACE I/D variant did differ significantly between hypertensives and controls (X(2)=13.98, P<0.05; X(2) =12.66, P<0.05, respectively) where a significant association between the D allele of the ACE I/D gene and essential hypertension has been observed (OR=0.46; 95%CI [0.27-0.75]). We reported a high prevalence of the D and T allele in hypertensives female. This study shows that the M235T variant of the AGT gene is not associated with essential hypertension while a significant association has been reported with the D allele in this sample of Algerian population of the Oran city.</description><subject>Adult</subject><subject>Algeria</subject><subject>Angiotensinogen - genetics</subject><subject>Case-Control Studies</subject><subject>Essential Hypertension</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><issn>0003-3898</issn><issn>1950-6112</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctuFDEQRS0EIpPHki3ykk0PfvaD3SgKECkSG7JuVXvKg1G33bjcoPmS_C49mcCqVKVzb5XqMvZOiq2sW_MRBrdVQtqtFHX3im1kZ0VVS6les40QQle67doLdkn0UwipWq3fsgtVm3UqzYY97YiSC1BCipzKsj_yAcsfxLVLE_KMMcQK4iGkgpHCOj5SwYkfMCL_DTlALMQh7jkSYSwBRv7jOGN-xlfTVQKcYJpH5Mnz3XjAk4jPaV7G572fuANC7lIsOY3nK67ZGw8j4c1LvWKPn---336tHr59ub_dPVROdbpU0CllGzEM1tSdsuCF16YBK7TtvMFW1g5QKRysdo3xznvjvG5E7fbYDA3qK_bh7Dvn9GtBKv0UyOE4QsS0UC8b1QprhNQrWp1RlxNRRt_POUyQj70U_SmLfs2iP2XRn7JY-fcv1ssw4f4__e_5-i_6J4k8</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Amrani, Asma</creator><creator>Baba Hamed, Mohamed Bey</creator><creator>Mesli Talebbendiab, Farida</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study</title><author>Amrani, Asma ; Baba Hamed, Mohamed Bey ; Mesli Talebbendiab, Farida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-a922570bb546925af0f347a50359f4e816cae22eb53c74fcff4cf3706cde7b7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Algeria</topic><topic>Angiotensinogen - genetics</topic><topic>Case-Control Studies</topic><topic>Essential Hypertension</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amrani, Asma</creatorcontrib><creatorcontrib>Baba Hamed, Mohamed Bey</creatorcontrib><creatorcontrib>Mesli Talebbendiab, Farida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annales de biologie clinique (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amrani, Asma</au><au>Baba Hamed, Mohamed Bey</au><au>Mesli Talebbendiab, Farida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study</atitle><jtitle>Annales de biologie clinique (Paris)</jtitle><addtitle>Ann Biol Clin (Paris)</addtitle><date>2015-09</date><risdate>2015</risdate><volume>73</volume><issue>5</issue><spage>557</spage><epage>563</epage><pages>557-563</pages><issn>0003-3898</issn><eissn>1950-6112</eissn><abstract>Essential hypertension is an important risk factor for the development of cardiovascular disease. We aim in this study to analyse the relationship between AGT M235T gene variant and ACE I/D gene variant with essential hypertension in a sample of the Algerian population of the Oran city. A case-control study has been performed in 145 subjects including; 75 hypertensives and 70 controls from Algerian population of Oran city. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to detect the M235T variant of angiotensinogen (AGT) gene and a nested PCR to determine ACE I/D gene variant. The genotypic and allelic distribution of the M235Tvariant of the AGT gene did not differ in hypertensives and normotensives group (X(2) =7.81, P<0.05; X(2) =4.67, respectively) thus there was no association between the T allele and hypertension (OR=1.64; 95%CI [1.01-2.69]). The genotypic and allelic frequencies of the ACE I/D variant did differ significantly between hypertensives and controls (X(2)=13.98, P<0.05; X(2) =12.66, P<0.05, respectively) where a significant association between the D allele of the ACE I/D gene and essential hypertension has been observed (OR=0.46; 95%CI [0.27-0.75]). We reported a high prevalence of the D and T allele in hypertensives female. This study shows that the M235T variant of the AGT gene is not associated with essential hypertension while a significant association has been reported with the D allele in this sample of Algerian population of the Oran city.</abstract><cop>France</cop><pmid>26489814</pmid><doi>10.1684/abc.2015.1069</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Algeria Angiotensinogen - genetics Case-Control Studies Essential Hypertension Female Gene Frequency Genetics, Population Genotype Humans Hypertension - genetics Male Middle Aged Polymerase Chain Reaction Polymorphism, Restriction Fragment Length |
| title | Association study between some renin-angiotensin system gene variants and essential hypertension in a sample of Algerian population: case control study |
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