Lamina Cribrosa Reversal after Trabeculectomy and the Rate of Progressive Retinal Nerve Fiber Layer Thinning

Purpose To determine whether the reversal of lamina cribrosa (LC) displacement observed after trabeculectomy is associated with the rate of progressive retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG). Design Observational case series. Participants Thirty-four patients with POAG who underwent trabeculectomy and were followed up for at least 2.5 years, during which the RNFL thickness was measured by serial spectral-domain (SD) optical coherence tomography (OCT). Methods The participants underwent enhanced depth imaging scanning of the optic nerve using SD OCT before surgery (PREOP), at a 6-month postoperative follow-up (FU1), and at a subsequent follow-up that was performed at least 2.5 years postoperatively (FU2), and serial RNFL thickness was measured at least 5 times during the study period. Preoperative and postoperative LC depths (LCDs) as determined on 7 selected B-scan images from each eye were averaged to produce the mean LCD. The rate of RNFL thinning was determined by linear regression of serial OCT RNFL thickness measurements over time. Main Outcome Measures Factors associated with the rate of OCT RNFL thinning. Results The intraocular pressure (IOP) decreased from 23.8±7.9 mmHg (mean ± standard deviation) to 11.0±4.4 mmHg at FU1 ( P < 0.001) and subsequently increased to 13.1±5.2 mmHg at an overall follow-up of 3.5±0.8 years ( P = 0.003). The LCD was reduced from 589.90±148.32 to 508.57±136.28 μm at FU1 ( P