Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy
Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging....
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| Veröffentlicht in: | ACS nano 2015-10, Vol.9 (10), p.9678-9690 |
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| container_title | ACS nano |
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| creator | Kang, Seokyung Bhang, Suk Ho Hwang, Sekyu Yoon, Jeong-Kee Song, Jaejung Jang, Hyeon-Ki Kim, Sungjee Kim, Byung-Soo |
| description | Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 °C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect. |
| doi_str_mv | 10.1021/acsnano.5b02207 |
| format | Article |
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However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 °C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/acsnano.5b02207</identifier><identifier>PMID: 26348606</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Cell Aggregation ; Drug Delivery Systems ; Female ; Gold - administration & dosage ; Gold - pharmacokinetics ; Gold - therapeutic use ; Hyperthermia, Induced - methods ; Mesenchymal Stromal Cells - cytology ; Metal Nanoparticles - administration & dosage ; Metal Nanoparticles - therapeutic use ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms - therapy ; Phototherapy - methods</subject><ispartof>ACS nano, 2015-10, Vol.9 (10), p.9678-9690</ispartof><rights>Copyright © American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a333t-5eb44425af8153e502274ce8b0eb21cf95fc7b2574ad321b31dec844838020cc3</citedby><cites>FETCH-LOGICAL-a333t-5eb44425af8153e502274ce8b0eb21cf95fc7b2574ad321b31dec844838020cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsnano.5b02207$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsnano.5b02207$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26348606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Seokyung</creatorcontrib><creatorcontrib>Bhang, Suk Ho</creatorcontrib><creatorcontrib>Hwang, Sekyu</creatorcontrib><creatorcontrib>Yoon, Jeong-Kee</creatorcontrib><creatorcontrib>Song, Jaejung</creatorcontrib><creatorcontrib>Jang, Hyeon-Ki</creatorcontrib><creatorcontrib>Kim, Sungjee</creatorcontrib><creatorcontrib>Kim, Byung-Soo</creatorcontrib><title>Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. However, improving their tumor-targeting efficiency and optimizing the nanoparticle size for maximizing the photothermal effect remain challenging. We demonstrate that mesenchymal stem cells (MSCs) can aggregate pH-sensitive gold nanoparticles (PSAuNPs) in mildly acidic endosomes, target tumors, and be used for photothermal therapy. These aggregated structures had a higher cellular retention in comparison to pH-insensitive, control AuNPs (cAuNPs), which is important for the cell-based delivery process. PSAuNP-laden MSCs (MSC-PSAuNPs) injected intravenously to tumor-bearing mice show a 37-fold higher tumor-targeting efficiency (5.6% of the injected dose) and 8.3 °C higher heat generation compared to injections of cAuNPs after irradiation, which results in a significantly enhanced anticancer effect.</description><subject>Animals</subject><subject>Cell Aggregation</subject><subject>Drug Delivery Systems</subject><subject>Female</subject><subject>Gold - administration & dosage</subject><subject>Gold - pharmacokinetics</subject><subject>Gold - therapeutic use</subject><subject>Hyperthermia, Induced - methods</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Metal Nanoparticles - administration & dosage</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Neoplasms - therapy</subject><subject>Phototherapy - methods</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLw0AUhQdRbK2u3cksBUk7z2SyLFWrUB9gBXdhMrnpgyRTZxKh_94prd25OnfxnXM5B6FrSoaUMDrSxje6sUOZE8ZIcoL6NOVxRFT8dXq8Je2hC-_XhMhEJfE56rGYCxWTuI_yF_DQmOW21hX-aKHGE6gqj8eLhYOFbgHrpsD3UK1-wOGprQr8Gh5utGtXpgKPW4vnXW2dx6V1-H1pW9suwe3i5kH1ZnuJzkpdebg66AB9Pj7MJ0_R7G36PBnPIs05byMJuRCCSV0qKjnIUCgRBlROIGfUlKksTZIzmQhdcEZzTgswSgjFFWHEGD5At_vcjbPfHfg2q1fehDa6Adv5jCYsSVUqUhLQ0R41znrvoMw2blVrt80oyXbDZodhs8OwwXFzCO_yGooj_7dkAO72QHBma9u5JnT9N-4X2I-Ecw</recordid><startdate>20151027</startdate><enddate>20151027</enddate><creator>Kang, Seokyung</creator><creator>Bhang, Suk Ho</creator><creator>Hwang, Sekyu</creator><creator>Yoon, Jeong-Kee</creator><creator>Song, Jaejung</creator><creator>Jang, Hyeon-Ki</creator><creator>Kim, Sungjee</creator><creator>Kim, Byung-Soo</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151027</creationdate><title>Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy</title><author>Kang, Seokyung ; Bhang, Suk Ho ; Hwang, Sekyu ; Yoon, Jeong-Kee ; Song, Jaejung ; Jang, Hyeon-Ki ; Kim, Sungjee ; Kim, Byung-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a333t-5eb44425af8153e502274ce8b0eb21cf95fc7b2574ad321b31dec844838020cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cell Aggregation</topic><topic>Drug Delivery Systems</topic><topic>Female</topic><topic>Gold - administration & dosage</topic><topic>Gold - pharmacokinetics</topic><topic>Gold - therapeutic use</topic><topic>Hyperthermia, Induced - methods</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Metal Nanoparticles - administration & dosage</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Neoplasms - therapy</topic><topic>Phototherapy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Seokyung</creatorcontrib><creatorcontrib>Bhang, Suk Ho</creatorcontrib><creatorcontrib>Hwang, Sekyu</creatorcontrib><creatorcontrib>Yoon, Jeong-Kee</creatorcontrib><creatorcontrib>Song, Jaejung</creatorcontrib><creatorcontrib>Jang, Hyeon-Ki</creatorcontrib><creatorcontrib>Kim, Sungjee</creatorcontrib><creatorcontrib>Kim, Byung-Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Seokyung</au><au>Bhang, Suk Ho</au><au>Hwang, Sekyu</au><au>Yoon, Jeong-Kee</au><au>Song, Jaejung</au><au>Jang, Hyeon-Ki</au><au>Kim, Sungjee</au><au>Kim, Byung-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2015-10-27</date><risdate>2015</risdate><volume>9</volume><issue>10</issue><spage>9678</spage><epage>9690</epage><pages>9678-9690</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Gold nanoparticles (AuNPs) have been extensively studied for photothermal cancer therapy because AuNPs can generate heat upon near-infrared irradiation. 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Cell Aggregation Drug Delivery Systems Female Gold - administration & dosage Gold - pharmacokinetics Gold - therapeutic use Hyperthermia, Induced - methods Mesenchymal Stromal Cells - cytology Metal Nanoparticles - administration & dosage Metal Nanoparticles - therapeutic use Mice Mice, Inbred BALB C Mice, Nude Neoplasms - therapy Phototherapy - methods |
| title | Mesenchymal Stem Cells Aggregate and Deliver Gold Nanoparticles to Tumors for Photothermal Therapy |
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