Mechanisms of anorexia–cachexia syndrome and rational for treatment with selective ghrelin receptor agonist

Highlights • Cancer cachexia is a multi-organ, multifactorial and often irreversible syndrome. • Treatment options for treating cancer cachexia are limited. • Nutritional counselling may be beneficial in delaying cachexia. • Anamorelin is a first-in-class, orally active ghrelin receptor agonist....

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Veröffentlicht in:	Cancer treatment reviews 2015-11, Vol.41 (9), p.793-797
Hauptverfasser:	Esposito, Angela, Criscitiello, Carmen, Gelao, Lucia, Pravettoni, Gabriella, Locatelli, Marzia, Minchella, Ida, Di Leo, Maria, Liuzzi, Rita, Milani, Alessandra, Massaro, Mariangela, Curigliano, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Anamorelin Animals Anorexia - drug therapy Anorexia - etiology Anorexia - metabolism Cachexia - drug therapy Cachexia - etiology Cachexia - metabolism Cancer cachexia Ghrelin receptor Hematology, Oncology and Palliative Medicine Humans Hydrazines - pharmacology Hydrazines - therapeutic use Neoplasms - complications Neoplasms - metabolism Oligopeptides - pharmacology Oligopeptides - therapeutic use Receptors, Ghrelin - agonists Receptors, Ghrelin - metabolism Syndrome
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Zusammenfassung:	Highlights • Cancer cachexia is a multi-organ, multifactorial and often irreversible syndrome. • Treatment options for treating cancer cachexia are limited. • Nutritional counselling may be beneficial in delaying cachexia. • Anamorelin is a first-in-class, orally active ghrelin receptor agonist.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.09.002